Letrozole Drug Description
Letrozole is a medication primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It functions as an aromatase inhibitor, which means it inhibits the enzyme responsible for converting androgens into estrogens, thereby reducing estrogen levels in the body. This decrease in estrogen can slow or stop the growth of certain types of breast tumors that require estrogen to grow.
How Letrozole Works
The mechanism of action for letrozole involves:
- Inhibition of aromatase enzyme activity.
- Reduction of circulating estrogen levels.
- Decreased stimulation of estrogen-sensitive tumors.
Indications for Use
Letrozole is indicated for various conditions, including:
- Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.
- Treatment of advanced breast cancer in postmenopausal women.
- Off-label use in fertility treatments for women with ovulatory disorders.
Dosing Information
The typical dosage of letrozole for adults is:
- 2.5 mg taken once daily.
- Duration of therapy often lasts for 5 years in adjuvant settings.
Potential Side Effects
Letrozole may cause side effects, which can vary in severity. Common side effects include:
- Hot flashes
- Joint pain
- Fatigue
- Nausea
- Bone thinning (osteoporosis)
FAQs About Letrozole
1. Who should not take Letrozole?
Letrozole should not be taken by individuals who are:
- Pregnant or breastfeeding.
- Allergic to letrozole or any of its ingredients.
- Pre-menopausal or have not been confirmed as menopausal.
2. Can Letrozole affect fertility?
Yes, while letrozole is primarily used for cancer treatment, it Letrozol – 1 A Pharma 2,5 mg drug description has been utilized off-label to promote ovulation in women facing infertility issues related to polycystic ovary syndrome (PCOS).
3. How long does it take for Letrozole to start working?
Many patients may begin to see therapeutic effects within a few weeks; however, optimal benefits may take several months of consistent usage.
Conclusion
Letrozole is a vital medication in managing specific types of breast cancer and can also play a role in fertility treatments. Understanding its function, potential side effects, and proper usage is crucial for both healthcare providers and patients. Always consult with a healthcare professional before starting any new medication.
